Murano vs Rx 350: Which Luxury Suv Reigns Supreme?

Versus
By Kylie Parker April 24, 2026
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Choosing between a luxury SUV can feel like navigating a maze of features and price points. For many discerning drivers, the decision often narrows down to two compelling options: the sophisticated Nissan Murano and the renowned Lexus RX 350. Both offer a blend of comfort, technology, and practicality, but they cater to slightly different priorities.

The Murano presents a stylish and comfortable cabin, often at a more accessible price point, making it an attractive proposition for those seeking premium features without the absolute top-tier cost. It aims to deliver a refined driving experience with a distinctive design.

On the other hand, the Lexus RX 350 has long been a benchmark in the luxury SUV segment, celebrated for its exceptional reliability, smooth ride, and upscale interior. It’s a vehicle that embodies quiet confidence and a dedication to passenger well-being.

Specs at a Glance

Featuremuranorx 350
Engine3.5L V62.4L Turbo-4
Horsepower260 hp275 hp
Torque240 lb-ft317 lb-ft
TransmissionCVT8-speed Automatic
DrivetrainFWD/AWDFWD/AWD
Seating Capacity75
Cargo Space (max)70.1 cu ft46.2 cu ft
Infotainment Screen8.0 inches9.8 inches
Apple CarPlay/Android AutoStandardStandard
Safety FeaturesStandard SuiteStandard Suite
Towing Capacity1,500 lbs4,000 lbs
Fuel Economy (combined est.)23 MPG25 MPG

Feature-by-Feature Breakdown

Engine and Performance

  • Murano: The Nissan Murano typically comes with a 3.5-liter V6 engine, offering a good balance of power for daily driving and highway cruising. While smooth, it’s not the most engaging powertrain and can feel a bit dated compared to some competitors. Fuel economy is respectable for its class.
  • Rx 350: The Lexus RX 350 is powered by a 3.5-liter V6 engine as well, often paired with an 8-speed automatic transmission. It delivers strong, refined acceleration and a comfortable, quiet ride. The RX 350 prioritizes a luxurious and effortless driving experience over sportiness.
  • Winner: RX 350

Interior Comfort and Luxury

  • Murano: The Murano’s interior is known for its “lounge-like” feel, with comfortable, supportive seats and a relatively upscale design for its price point. Material quality is generally good, but some plastics can betray its non-luxury positioning. Cabin noise is well-managed.
  • Rx 350: Lexus is renowned for its plush and meticulously crafted interiors. The RX 350 boasts high-quality materials, excellent fit and finish, and exceptionally comfortable seats. The cabin is exceptionally quiet, creating a serene environment.
  • Winner: RX 350

Infotainment and Technology

  • Murano: The Murano offers a decent infotainment system with standard Apple CarPlay and Android Auto. Screen size is adequate, and the interface is generally user-friendly, though it might not be the most cutting-edge. Available features include a premium audio system.
  • Rx 350: The RX 350’s infotainment system has historically been a point of contention due to its quirky touchpad controller. While it offers desirable features like navigation and a premium Mark Levinson audio option, the user interface can be distracting. Newer models have improved, but the touchpad remains.
  • Winner: Murano

Cargo Space and Practicality

  • Murano: The Murano offers a generous amount of cargo space, making it practical for families and hauling gear. The rear seats fold down easily to expand the cargo area. Its sloping roofline, while stylish, can slightly compromise maximum cargo height.
  • Rx 350: The RX 350 provides a good amount of cargo capacity, sufficient for most daily needs and occasional trips. However, it generally offers less overall cargo volume than the Murano, especially with the rear seats up. The squared-off rear design aids in loading.
  • Winner: Murano

Safety Features and Ratings

  • Murano: The Murano typically comes with a suite of standard safety features, including automatic emergency braking, blind-spot monitoring, and rear cross-traffic alert. It generally receives good safety ratings from IIHS and NHTSA, making it a solid choice for safety-conscious buyers.
  • Rx 350: The RX 350 also comes equipped with a comprehensive suite of advanced safety technologies as standard, often including adaptive cruise control and lane-keeping assist. It consistently earns top safety scores, reflecting Lexus’ commitment to occupant protection.
  • Winner: RX 350

Ride Quality and Handling

  • Murano: The Murano excels in providing a comfortable and compliant ride, absorbing road imperfections effectively. Its handling is predictable and stable, but it leans towards a more relaxed driving experience rather than sporty agility. The continuously variable transmission (CVT) contributes to smooth acceleration.
  • Rx 350: The RX 350 is designed for supreme comfort. Its suspension is tuned to deliver a pillowy-smooth ride, isolating occupants from the road. While not sporty, its handling is secure and confidence-inspiring for everyday driving, with minimal body roll.
  • Winner: RX 350

Exterior Styling

  • Murano: The Nissan Murano features a distinctive and bold exterior design with a flowing, sculptural body. Its “floating roof” design and aggressive front fascia give it a modern and stylish appearance that stands out in its segment.
  • Rx 350: The Lexus RX 350 sports a more aggressive and angular design, characterized by its prominent spindle grille and sharp body lines. While some find it polarizing, it undeniably gives the RX a strong visual presence and a more upscale, contemporary look.
  • Winner: RX 350

Value and Price

  • Murano: The Nissan Murano generally positions itself as a more affordable option in the mid-size SUV segment, offering a strong value proposition for its features and comfort. It provides a near-luxury experience at a more accessible price point.
  • Rx 350: As a premium luxury SUV, the Lexus RX 350 comes with a higher price tag. However, it justifies this with its superior build quality, refined driving dynamics, and luxury brand cachet, offering strong resale value.
  • Winner: Murano

Winner by Category

CategoryWinner
Space & Versatilitymurano
Performance & Driving Dynamicsrx 350
Luxury & Interior Qualityrx 350
Fuel Efficiencyrx 350
Value for Moneymurano
Towing Capabilityrx 350

What They Have in Common

  • Powertrain Options: Both vehicles offer a choice between front-wheel drive and all-wheel drive, providing flexibility for different driving conditions and preferences.
  • Infotainment Systems: Both come standard with Apple CarPlay and Android Auto integration, ensuring seamless connectivity for your smartphone and access to your favorite apps.
  • Comprehensive Safety Suites: Buyers of either the Murano or the RX 350 can expect a robust suite of standard safety and driver-assistance features, designed to enhance awareness and prevent accidents.
  • Comfortable Interiors: Both SUVs are designed with passenger comfort in mind, offering well-appointed cabins with quality materials and supportive seating for everyday journeys.
  • Modern Styling: Each vehicle presents a contemporary and stylish exterior design that appeals to a broad range of tastes in the competitive SUV market.

Murano Vs Rx 350 Buying Guide

Performance and Driving Dynamics

The Nissan Murano typically offers a comfortable and composed ride, prioritizing a smooth experience for everyday commuting. Its V6 engine provides adequate power for most situations, but it’s generally tuned for refinement rather than outright sportiness. The handling is predictable and stable, making it a relaxed driver’s car.

In contrast, the Lexus RX 350 leans more towards a luxurious and serene driving experience. While not a performance machine, its powertrain is smooth and responsive, offering a quiet cabin even at highway speeds. The suspension is adept at absorbing road imperfections, contributing to its reputation for comfort and a premium feel. (See Also: Apple Iphone 14 Vs 15 )

Interior Comfort and Features

The Murano’s interior is often praised for its upscale design and comfortable seating, especially in higher trims. It provides ample space for passengers and decent cargo capacity. Standard features are usually generous, with available advanced safety technologies and infotainment options that cater to modern needs, though the infotainment system can feel a bit dated compared to some rivals.

The RX 350 excels in creating a luxurious and technologically advanced cabin. High-quality materials, meticulous craftsmanship, and a quiet environment are hallmarks of the Lexus experience. It boasts a comprehensive suite of standard and available features, including advanced driver aids, a user-friendly infotainment system, and premium audio options, all contributing to a sophisticated and enjoyable passenger experience.

Reliability and Maintenance

Nissan generally has a decent reputation for reliability, and the Murano is no exception. While not always at the top of its class, it typically proves to be a dependable vehicle for its owners. Routine maintenance is usually straightforward, and parts are readily available, contributing to reasonable long-term ownership costs. However, some owners have reported occasional electronic glitches.

Lexus has consistently ranked at the top for reliability, and the RX 350 is a prime example of this. Its robust engineering and rigorous quality control mean fewer unexpected repairs and a consistently dependable ownership experience. Maintenance costs, while potentially higher than a mainstream brand, are often offset by the vehicle’s longevity and the premium service typically offered by Lexus dealerships. (See Also: Texas Vs Wyoming Llc )

Value and Resale

The Nissan Murano often presents a strong value proposition, especially when considering its comfortable ride and upscale interior at a competitive price point. It tends to depreciate at a moderate rate, making it a reasonable choice for those looking for a well-equipped SUV without the premium price tag. Its appeal lies in offering a blend of features and comfort at a more accessible cost.

The Lexus RX 350 typically holds its value exceptionally well, a testament to its strong brand reputation, reliability, and enduring appeal. While its initial purchase price is higher, the excellent resale value can significantly offset the long-term cost of ownership. This makes it an attractive option for buyers who prioritize a premium vehicle that maintains its worth over time.

Who Should Buy What?

Buy murano If…

  • You need seating for up to seven passengers.
  • You prioritize a comfortable and spacious ride for family road trips.
  • You are looking for a more budget-friendly option in the mid-size SUV segment.
  • You appreciate a smooth and refined driving experience.

Buy rx 350 If…

  • You prefer a more engaging and sporty driving dynamic.
  • You need a higher towing capacity for recreational activities.
  • You value a premium interior with advanced technology and luxury appointments.
  • You are looking for a reliable and well-built compact luxury SUV.

Frequently Asked Questions

Which is more fuel-efficient, the Murano or the RX 350?

Generally, the Lexus RX 350, especially in its hybrid variants, tends to offer better fuel efficiency compared to the Nissan Murano. While both have V6 engines, the RX 350’s powertrain is often optimized for a balance of power and economy, and the availability of a hybrid option provides a significant advantage for those prioritizing MPG.

Is the Murano or RX 350 better for families?

Both vehicles offer comfortable seating for families, but the Lexus RX 350 often provides a more refined and quiet cabin experience, which can be beneficial for long trips with children. The RX 350’s interior materials are also typically more durable and easier to clean. However, the Murano offers competitive passenger space and practicality. (See Also: Swagbucks Vs Survey Junkie )

Which has better cargo space?

Cargo space can be quite comparable between the two, with both offering a decent amount of room for groceries, luggage, and sports equipment. It’s worth checking the specific model year and trim levels, as cargo dimensions can vary. Often, the Murano might offer a slight edge in overall cubic feet, but the RX 350’s well-designed cargo area is highly functional.

Which offers a more engaging driving experience?

Neither vehicle is designed for outright sporty driving, but the RX 350 often provides a slightly more responsive throttle and a more connected feel to the road, contributing to a more engaging, albeit still comfortable, experience. The Murano prioritizes a smoother, more isolated ride, which might feel less engaging to some drivers.

Which is more luxurious?

The Lexus RX 350 is consistently lauded for its luxurious interior, featuring premium materials, meticulous craftsmanship, and a serene cabin environment. While the Nissan Murano offers a well-appointed and comfortable interior, especially in its higher trims, it generally doesn’t reach the same level of opulence and refinement as the RX 350.

Final Verdict

The Nissan Murano offers a compelling blend of comfort, style, and value, making it a solid choice for those seeking a practical and well-equipped mid-size SUV. However, the Lexus RX 350 stands out with its unparalleled luxury, exceptional reliability, and superior refinement. For buyers prioritizing a premium ownership experience and long-term dependability, the RX 350 is the clear winner.

Winner: Lexus RX 350